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KMID : 1023920130150040033
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Journal of the Korean Academy of Kinesiology
2013 Volume.15 No. 4 p.33 ~ p.40
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Effects of Short-term Swimming Exercise Training on Lactate Levels, MCT 1 Contents and Circulating Ketone Bodies in Rat Skeletal Muscle
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Lee Ho-Seong
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Abstract
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INTRODUCTION: The purpose of this study was to examine the effect of short-term swimming exercise training on lactate levels, MCT 1 contents and circulating ketone bodies in rat skeletal muscle.
METHOD: Male Sprague-Dawley rats (N=32) were performed swimming exercise training for 60 minute/day and 7 days/week, for 3 weeks. Lactate in rat skeletal muscle was measured immediately after (IA, n=8), and MCT 1 protein in soleus muscle, extensor digitorum longus muscle and liver were measured before exercise (pre, n=8), after 7 days (7D, n=8) and 21 days (21D, n=8). In Glucocorticoid administration, Male Sprague-Dawley rats (N=14) were assigned to administration group (AG, n=7) and control group (CON, n=7). Administration group was subcutaneous injected prednisolone acetate (2mg/kg) and normal saline in control group, for 4 days, and than MCT 1 protein and blood ketone body were measured after injections.
RESULT: Lactate concentration in soleus muscle and extensor digitorum longus muscle were significantly increased immediately after of swimming exercise training compared with before exercise (p=.005, p=.008 respectively). MCT 1 protein in soleus muscle, extensor digitorum longus muscle were significantly increased after both 7 and 21 days of swimming exercise training compared with before exercise (p=.032, p=.005; p=.037, p=.028 respectively), and MCT 1 protein in liver was significantly increased after 21 days of swimming exercise training (p=.037). In Glucocorticoid administration, MCT 1 protein in liver and blood ketone body concentration were significantly increased in the administration group than in the control group (p=.027, p=.021 respectively).
CONCLUSION: These results suggest that product of intracellular endogenous monocarboxylic and proton induces MCT 1 in the skeletal muscle and liver during short-term swimming exercise training.
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KEYWORD
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Swimming exercise training, Skeletal muscle, Lactate, Monocarboxylate transporter 1, Ketone body
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